ea0033oc3.3 | Oral Communications 3 | BSPED2013
Senniappan Senthil
, Alexandrescu Sanda
, Tatevian Nina
, Shah Pratik
, Arya Ved
, Flanagan Sarah
, Ellard Sian
, Rampling Dyanne
, Ashworth Michael
, Brown Robert
, Hussain Khalid
Introduction: Hyperinsulinaemic hypoglycaemia (HH) is the most common cause of severe and persistent hypoglycaemia in neonates. The treatment of diazoxide unresponsive HH involves pancreatectomy. Mammalian target of rapamycin (mTOR) is a protein kinase that regulates cellular proliferation. We aimed to evaluate the efficacy of mTOR inhibitor Sirolimus and assess mTOR expression in the pancreas of infants with severe HH.Methods: Four infants with severe, ...